Method for correction morphodensitometric parameters of trabecular tissue of vertebrae based on CT reconstruction of a composite body phantom
Keywords:
оsteoporosis, vertebral fracture, bone mineral density, trabecular tissue morphometry parameters, Micro CT, composite CT phantomAbstract
The article presents the results of the development and validation of a method for quantitative assessment of human bone status by using phantom CT models of the vertebra to adapt routine CT examinations of the human spine to the needs of specialized densitometric analysis of vertebral bodies. A composite digital phantom of the vertebral body was developed, reflecting the trabecular architecture of the vertebral body, its cortical shell, and surrounding soft tissues. For the first time an algorithm for modeling systemic bone degradation as a process of simultaneous thinning of trabeculae and cortex was proposed. The "Global Reference Normalization" (GRN) method was implemented to minimize hardware-related errors. The "Error Crossover" effect was identified, and a linear correction formula was derived. The proposed approach brings the accuracy of clinical CT close to the level of micro-CT, creating new opportunities for the early diagnosis of osteoporosis.
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